Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50040705
Substrate
n/a
Meas. Tech.
ChEMBL_38119 (CHEMBL650074)
IC50
41600000±n/a nM
Citation
 So, SS; Karplus, M Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. J Med Chem 39:5246-56 (1997) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50040705
Synonyms:
5-Phenyl-7-vinyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one | CHEMBL346836 | Ro-20-5747
Type:
Small organic molecule
Emp. Form.:
C17H14N2O
Mol. Mass.:
262.3059
SMILES:
C=Cc1ccc2NC(=O)CN=C(c3ccccc3)c2c1 |t:10|
Structure:
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