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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50081975
Substrate
n/a
Meas. Tech.
ChEMBL_2254 (CHEMBL617198)
IC50
7943.28±n/a nM
Citation
 Prunier, H; Rault, S; Lancelot, JC; Robba, M; Renard, P; Delagrange, P; Pfeiffer, B; Caignard, DH; Misslin, R; Guardiola-Lemaitre, B; Hamon, M Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. J Med Chem 40:1808-19 (1997) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT2A | 5HT2A_BOVIN | 5HTR2A | HTR2A | Serotonin 2a (5-HT2a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52578.24
Organism:
BOVINE
Description:
5-HT2A HTR2A BOVINE::Q75Z89
Residue:
470
Sequence:
MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
  
Inhibitor
Name:
BDBM50081975
Synonyms:
6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1,2-a]pyrazine | CHEMBL54914
Type:
Small organic molecule
Emp. Form.:
C15H17N5
Mol. Mass.:
267.329
SMILES:
CN1CCN(CC1)c1nc2cccnc2n2cccc12
Structure:
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