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Target
Tubulin alpha-1A chain
Ligand
BDBM50059961
Substrate
n/a
Meas. Tech.
ChEMBL_212206 (CHEMBL817769)
IC50
724.44±n/a nM
Citation
 Zhang, SX; Feng, J; Kuo, SC; Brossi, A; Hamel, E; Tropsha, A; Lee, KH Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis. J Med Chem 43:167-76 (2000) [PubMed]  Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Sus scrofa (Pig)
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM50059961
Synonyms:
2-(3-Chloro-phenyl)-6-methyl-1H-[1,8]naphthyridin-4-one | 2-(3-chlorophenyl)-6-methyl-1,8-naphthyridin-4(1H)-one | CHEMBL49827 | NSC-679036
Type:
Small organic molecule
Emp. Form.:
C15H11ClN2O
Mol. Mass.:
270.714
SMILES:
Cc1cnc2nc(cc(O)c2c1)-c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: