Reaction Details Report a problem with these data
Target
Protein Tat
Ligand
BDBM50410417
Substrate
n/a
Meas. Tech.
ChEMBL_320712 (CHEMBL881698)
Temperature
298.15±n/a K
Kd
7700±n/a nM
Comments
extracted
Citation
 Lee, CW; Cao, H; Ichiyama, K; Rana, TM Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine. Bioorg Med Chem Lett 15:4243-6 (2005) [PubMed]  Article 
Target
Name:
Protein Tat
Synonyms:
Human immunodeficiency virus type 1 Tat protein | TAT_HV1H2 | tat
Type:
PROTEIN
Mol. Mass.:
9851.32
Organism:
Human immunodeficiency virus type 1 (isolate HXB2 group M subtype B)(HIV-1)
Description:
ChEMBL_320712
Residue:
86
Sequence:
MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQNSQTHQASLSKQPTSQPRGDPTGPKE
  
Inhibitor
Name:
BDBM50410417
Synonyms:
CHEMBL371627
Type:
Small organic molecule
Emp. Form.:
C23H42N8O7
Mol. Mass.:
542.629
SMILES:
NCCCC[C@H](COC(N)=O)NC(=O)CN(CCCCN)C(=O)OC[C@@H](N)CCCNc1c(N)c(=O)c1=O
Structure:
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