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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50411052
Substrate
n/a
Meas. Tech.
ChEMBL_372592 (CHEMBL868679)
IC50
6160±n/a nM
Citation
 Brugel, TA; Maier, JA; Clark, MP; Sabat, M; Golebiowski, A; Bookland, RG; Laufersweiler, MJ; Laughlin, SK; Vanrens, JC; De, B; Hsieh, LC; Mekel, MJ; Janusz, MJ Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1. Bioorg Med Chem Lett 16:3510-3 (2006) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50411052
Synonyms:
CHEMBL208932
Type:
Small organic molecule
Emp. Form.:
C25H21ClFN5O
Mol. Mass.:
461.919
SMILES:
C[C@H](Nc1nccc(n1)N(C(=O)Nc1ccccc1Cl)c1cccc(F)c1)c1ccccc1
Structure:
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