Reaction Details Report a problem with these data
Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50202590
Substrate
n/a
Meas. Tech.
ChEMBL_423821 (CHEMBL910656)
IC50
470±n/a nM
Citation
 Solomon, VR; Haq, W; Srivastava, K; Puri, SK; Katti, SB Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives. J Med Chem 50:394-8 (2007) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50202590
Synonyms:
2-(4-chloro-phenyl)-3-[2-(7-chloroquinolin-4-ylamino)-ethyl]-[1,3]thiazinan-4-one | 2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)-1,3-thiazinan-4-one | CHEMBL219444
Type:
Small organic molecule
Emp. Form.:
C21H19Cl2N3OS
Mol. Mass.:
432.366
SMILES:
Clc1ccc(cc1)C1SCCC(=O)N1CCNc1ccnc2cc(Cl)ccc12
Structure:
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