Reaction Details Report a problem with these data
Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50202598
Substrate
n/a
Meas. Tech.
ChEMBL_423821 (CHEMBL910656)
IC50
450±n/a nM
Citation
 Solomon, VR; Haq, W; Srivastava, K; Puri, SK; Katti, SB Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives. J Med Chem 50:394-8 (2007) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50202598
Synonyms:
3-[2-(7-chloroquinolin-4-ylamino)-ethyl]-2-(2,6-dichloro-phenyl)-[1,3]thiazinan-4-one | CHEMBL374418
Type:
Small organic molecule
Emp. Form.:
C21H18Cl3N3OS
Mol. Mass.:
466.811
SMILES:
Clc1ccc2c(NCCN3C(SCCC3=O)c3c(Cl)cccc3Cl)ccnc2c1
Structure:
Search PDB for entries with ligand similarity: