Reaction Details Report a problem with these data
Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50202589
Substrate
n/a
Meas. Tech.
ChEMBL_423821 (CHEMBL910656)
IC50
460±n/a nM
Citation
 Solomon, VR; Haq, W; Srivastava, K; Puri, SK; Katti, SB Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives. J Med Chem 50:394-8 (2007) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50202589
Synonyms:
2-(4-chloro-phenyl)-3-[3-(7-chloroquinolin-4-ylamino)-propyl]-2,3-dihydrobenzo[e][1,3]thiazin-4-one | 2-(4-chlorophenyl)-3-(3-(7-chloroquinolin-4-ylamino)propyl)-2H-benzo[e][1,3]thiazin-4(3H)-one | CHEMBL376236
Type:
Small organic molecule
Emp. Form.:
C26H21Cl2N3OS
Mol. Mass.:
494.435
SMILES:
Clc1ccc(cc1)C1Sc2ccccc2C(=O)N1CCCNc1ccnc2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: