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Target
P2X purinoceptor 7
Ligand
BDBM50412140
Substrate
n/a
Meas. Tech.
ChEMBL_556618 (CHEMBL958117)
IC50
141.25±n/a nM
Citation
 Nelson, DW; Sarris, K; Kalvin, DM; Namovic, MT; Grayson, G; Donnelly-Roberts, DL; Harris, R; Honore, P; Jarvis, MF; Faltynek, CR; Carroll, WA Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists. J Med Chem 51:3030-4 (2008) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50412140
Synonyms:
CHEMBL494815
Type:
Small organic molecule
Emp. Form.:
C22H22FN3O
Mol. Mass.:
363.428
SMILES:
Fc1cccc(c1)C1(CCCCC1)C(=O)NNc1cccc2ncccc12
Structure:
Search PDB for entries with ligand similarity: