Reaction Details Report a problem with these data
Target
Alpha-2C adrenergic receptor
Ligand
BDBM50019848
Substrate
n/a
Meas. Tech.
ChEMBL_487925 (CHEMBL1016579)
Ki
18±n/a nM
Citation
 Gentili, F; Cardinaletti, C; Vesprini, C; Carrieri, A; Ghelfi, F; Farande, A; Giannella, M; Piergentili, A; Quaglia, W; Laurila, JM; Huhtinen, A; Scheinin, M; Pigini, M Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. J Med Chem 51:4289-99 (2008) [PubMed]  Article 
Target
Name:
Alpha-2C adrenergic receptor
Synonyms:
ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
49552.32
Organism:
Homo sapiens (Human)
Description:
P18825
Residue:
462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
  
Inhibitor
Name:
BDBM50019848
Synonyms:
2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole | 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1H-imidazole | CHEMBL10316 | Idazoxan | US8633208, Idazoxan
Type:
Small organic molecule
Emp. Form.:
C11H12N2O2
Mol. Mass.:
204.2252
SMILES:
C1CN=C(N1)C1COc2ccccc2O1 |c:2|
Structure:
Search PDB for entries with ligand similarity: