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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM23592
Substrate
n/a
Meas. Tech.
ChEMBL_510888 (CHEMBL997780)
IC50
269.77±n/a nM
Citation
 Singh, S; Soni, LK; Gupta, MK; Prabhakar, YS; Kaskhedikar, SG QSAR studies on benzoylaminobenzoic acid derivatives as inhibitors of beta-ketoacyl-acyl carrier protein synthase III. Eur J Med Chem 43:1071-80 (2008) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III | FABH_ENTFA | KAS III | beta-Ketoacyl-ACP Synthase III (FabH) | fabH
Type:
Acyltransferase; homodimer
Mol. Mass.:
35176.53
Organism:
Enterococcus faecalis
Description:
The E. faecalis FabH was cloned, and protein was expressed in E. coli.
Residue:
321
Sequence:
MKNYARISCTSRYVPENCVTNHQLSEMMDTSDEWIHSRTGISERRIVTQENTSDLCHQVAKQLLEKSGKQASEIDFILVATVTPDFNMPSVACQVQGAIGATEAFAFDISAACSGFVYALSMAEKLVLSGRYQTGLVIGGETFSKMLDWTDRSTAVLFGDGAAGVLIEAAETPHFLNEKLQADGQRWAALTSGYTINESPFYQGHKQASKTLQMEGRSIFDFAIKDVSQNILSLVTDETVDYLLLHQANVRIIDKIARKTKISREKFLTNMDKYGNTSAASIPILLDEAVENGTLILGSQQRVVLTGFGGGLTWGSLLLTL
  
Inhibitor
Name:
BDBM23592
Synonyms:
(3-Phenoxybenzoylamino)benzoic acid deriv., 23i | 2-{[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxybenzene]amido}benzoic acid
Type:
Small organic molecule
Emp. Form.:
C27H28N2O4
Mol. Mass.:
444.5222
SMILES:
CC1CC(C)CN(C1)c1ccc(cc1Oc1ccccc1)C(=O)Nc1ccccc1C(O)=O
Structure:
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