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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50416139
Substrate
n/a
Meas. Tech.
ChEMBL_635230 (CHEMBL1117841)
IC50
6309.57±n/a nM
Citation
 Budzik, B; Garzya, V; Shi, D; Walker, G; Lauchart, Y; Lucas, AJ; Rivero, RA; Langmead, CJ; Watson, J; Wu, Z; Forbes, IT; Jin, J 2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling. Bioorg Med Chem Lett 20:3545-9 (2010) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50416139
Synonyms:
CHEMBL1082365
Type:
Small organic molecule
Emp. Form.:
C20H21ClF2N2O
Mol. Mass.:
378.843
SMILES:
C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1 |r|
Structure:
Search PDB for entries with ligand similarity: