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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50416144
Substrate
n/a
Meas. Tech.
ChEMBL_635221 (CHEMBL1117832)
EC50
>10000±n/a nM
Citation
 Budzik, B; Garzya, V; Shi, D; Walker, G; Lauchart, Y; Lucas, AJ; Rivero, RA; Langmead, CJ; Watson, J; Wu, Z; Forbes, IT; Jin, J 2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling. Bioorg Med Chem Lett 20:3545-9 (2010) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50416144
Synonyms:
CHEMBL1083924
Type:
Small organic molecule
Emp. Form.:
C20H19ClFN3O
Mol. Mass.:
371.836
SMILES:
Fc1cccc(-c2cccc(Cl)c2)c1-c1noc(CC2CCNCC2)n1
Structure:
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