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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50416149
Substrate
n/a
Meas. Tech.
ChEMBL_635221 (CHEMBL1117832)
EC50
158.49±n/a nM
Citation
 Budzik, B; Garzya, V; Shi, D; Walker, G; Lauchart, Y; Lucas, AJ; Rivero, RA; Langmead, CJ; Watson, J; Wu, Z; Forbes, IT; Jin, J 2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling. Bioorg Med Chem Lett 20:3545-9 (2010) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50416149
Synonyms:
CHEMBL1083317
Type:
Small organic molecule
Emp. Form.:
C19H16Cl2F2N2O
Mol. Mass.:
397.246
SMILES:
FC1=C(CNC(=O)c2c(F)c(Cl)ccc2-c2cccc(Cl)c2)CCNC1 |c:1|
Structure:
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