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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50416240
Substrate
n/a
Meas. Tech.
ChEMBL_635571 (CHEMBL1118806)
IC50
398.11±n/a nM
Citation
 Budzik, B; Garzya, V; Shi, D; Foley, JJ; Rivero, RA; Langmead, CJ; Watson, J; Wu, Z; Forbes, IT; Jin, J 2' biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR. Bioorg Med Chem Lett 20:3540-4 (2010) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50416240
Synonyms:
CHEMBL1083723
Type:
Small organic molecule
Emp. Form.:
C20H23ClN2O
Mol. Mass.:
342.862
SMILES:
Cc1ccc(cc1Cl)-c1ccccc1C(=O)NCC1CCNCC1
Structure:
Search PDB for entries with ligand similarity: