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Target
Substance-K receptor
Ligand
BDBM50418026
Substrate
n/a
Meas. Tech.
ChEMBL_728300 (CHEMBL1687457)
Ki
3.24±n/a nM
Citation
 Ettorre, A; D'Andrea, P; Mauro, S; Porcelloni, M; Rossi, C; Altamura, M; Catalioto, RM; Giuliani, S; Maggi, CA; Fattori, D hNK2 receptor antagonists. The use of intramolecular hydrogen bonding to increase solubility and membrane permeability. Bioorg Med Chem Lett 21:1807-9 (2011) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50418026
Synonyms:
CHEMBL1683148
Type:
Small organic molecule
Emp. Form.:
C38H48FN5O4
Mol. Mass.:
657.8172
SMILES:
Fc1cc(ccc1C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC1CCN(CC2CCOCC2)CC1)-n1cccc1 |r|
Structure:
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