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Target
Histamine H4 receptor
Ligand
BDBM50418058
Substrate
n/a
Meas. Tech.
ChEMBL_735236 (CHEMBL1694498)
EC50
1±n/a nM
Citation
 Wijtmans, M; de Graaf, C; de Kloe, G; Istyastono, EP; Smit, J; Lim, H; Boonnak, R; Nijmeijer, S; Smits, RA; Jongejan, A; Zuiderveld, O; de Esch, IJ; Leurs, R Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity. J Med Chem 54:1693-703 (2011) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50418058
Synonyms:
CHEMBL1688946
Type:
Small organic molecule
Emp. Form.:
C15H23N5
Mol. Mass.:
273.3766
SMILES:
C(Cc1cnc[nH]1)Cn1cc(CC2CCCCC2)nn1
Structure:
Search PDB for entries with ligand similarity: