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Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Ligand
BDBM50348343
Substrate
n/a
Meas. Tech.
ChEMBL_757614 (CHEMBL1804871)
IC50
1070±n/a nM
Citation
 Gage, JL; Onrust, R; Johnston, D; Osnowski, A; Macdonald, W; Mitchell, L; Urögdi, L; Rohde, A; Harbol, K; Gragerov, S; Dormán, G; Wheeler, T; Florio, V; Cutshall, NS N-Acylhydrazones as inhibitors of PDE10A. Bioorg Med Chem Lett 21:4155-9 (2011) [PubMed]  Article 
Target
Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Synonyms:
PDE10_MOUSE | Pde10a
Type:
PROTEIN
Mol. Mass.:
89407.64
Organism:
Mus musculus
Description:
ChEMBL_1458264
Residue:
790
Sequence:
MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKSTPEKLNVKVED
  
Inhibitor
Name:
BDBM50348343
Synonyms:
CHEMBL1800314
Type:
Small organic molecule
Emp. Form.:
C16H18N4O4S
Mol. Mass.:
362.404
SMILES:
COc1cc(\C=N\NC(=O)CSc2ccncn2)cc(OC)c1OC
Structure:
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