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Target
Cholecystokinin receptor type A
Ligand
BDBM50418879
Substrate
n/a
Meas. Tech.
ChEMBL_757822 (CHEMBL1809766)
Ki
2238.72±n/a nM
Citation
 Roberts, K; Ursini, A; Barnaby, R; Cassarà, PG; Corsi, M; Curotto, G; Donati, D; Feriani, A; Finizia, G; Marchioro, C; Niccolai, D; Oliosi, B; Polinelli, S; Ratti, E; Reggiani, A; Tedesco, G; Tranquillini, ME; Trist, DG; van Amsterdam, FT Synthesis and structure-activity relationship of new 1,5-dialkyl-1,5-benzodiazepines as cholecystokinin-2 receptor antagonists. Bioorg Med Chem 19:4257-73 (2011) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49676.37
Organism:
RAT
Description:
Cholecystokinin central 0 RAT::P30551
Residue:
444
Sequence:
MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
  
Inhibitor
Name:
BDBM50418879
Synonyms:
CHEMBL1808417
Type:
Small organic molecule
Emp. Form.:
C33H40FN5O4
Mol. Mass.:
589.7002
SMILES:
Fc1ccc2N(CC34CC5CC(CC(C5)C3)C4)C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(CCN3CCOCC3)c2c1 |TLB:16:7:14:11.10.12,6:7:10:14.13.12,THB:16:11:14:7.15.8,15:13:10:16.7.8,15:7:10:14.13.12|
Structure:
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