Reaction Details Report a problem with these data
Target
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Ligand
BDBM50419063
Substrate
n/a
Meas. Tech.
ChEMBL_767271 (CHEMBL1825383)
IC50
>199526.23±n/a nM
Citation
 McClure, KJ; Maher, M; Wu, N; Chaplan, SR; Eckert, WA; Lee, DH; Wickenden, AD; Hermann, M; Allison, B; Hawryluk, N; Breitenbucher, JG; Grice, CA Discovery of a novel series of selective HCN1 blockers. Bioorg Med Chem Lett 21:5197-201 (2011) [PubMed]  Article 
Target
Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Synonyms:
HCN4 | HCN4_HUMAN
Type:
PROTEIN
Mol. Mass.:
129069.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454251
Residue:
1203
Sequence:
MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLPSNL
  
Inhibitor
Name:
BDBM50419063
Synonyms:
CHEMBL1823678
Type:
Small organic molecule
Emp. Form.:
C20H31N3O
Mol. Mass.:
329.4796
SMILES:
CN1CCN(CC1)C1(CNC(=O)c2ccccc2C)CCCCC1
Structure:
Search PDB for entries with ligand similarity: