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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50419491
Substrate
n/a
Meas. Tech.
ChEMBL_789189 (CHEMBL1924273)
IC50
0.2±n/a nM
Citation
 Mete, A; Bowers, K; Chevalier, E; Donald, DK; Edwards, H; Escott, KJ; Ford, R; Grime, K; Millichip, I; Teobald, B; Russell, V The discovery of AZD9164, a novel muscarinic M3 antagonist. Bioorg Med Chem Lett 21:7440-6 (2011) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50419491
Synonyms:
CHEMBL1921927
Type:
Small organic molecule
Emp. Form.:
C31H43N2O2
Mol. Mass.:
475.6848
SMILES:
C[C@@](N1CCCCC1)(C(=O)O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)c1ccccc1 |r,wU:1.0,wD:1.8,11.11,(27.45,-44.75,;27.46,-43.2,;27.46,-41.66,;28.8,-40.89,;28.79,-39.35,;27.46,-38.57,;26.12,-39.35,;26.11,-40.9,;28.8,-43.98,;28.81,-45.52,;30.14,-43.2,;31.48,-43.97,;31.48,-45.52,;32.82,-46.28,;32.87,-47.82,;34.22,-48.55,;35.53,-47.74,;36.89,-48.46,;38.19,-47.64,;39.55,-48.37,;40.85,-47.56,;40.8,-46.02,;39.43,-45.29,;38.13,-46.11,;34.16,-45.52,;34.16,-43.97,;32.82,-43.18,;32.04,-44.51,;33.52,-44.91,;26.13,-43.98,;24.8,-43.22,;23.47,-43.99,;23.48,-45.53,;24.82,-46.29,;26.15,-45.51,)|
Structure:
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