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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50419506
Substrate
n/a
Meas. Tech.
ChEMBL_789189 (CHEMBL1924273)
IC50
0.126±n/a nM
Citation
 Mete, A; Bowers, K; Chevalier, E; Donald, DK; Edwards, H; Escott, KJ; Ford, R; Grime, K; Millichip, I; Teobald, B; Russell, V The discovery of AZD9164, a novel muscarinic M3 antagonist. Bioorg Med Chem Lett 21:7440-6 (2011) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50419506
Synonyms:
CHEMBL1924049
Type:
Small organic molecule
Emp. Form.:
C29H38FN2O2
Mol. Mass.:
465.6221
SMILES:
C[C@@](N1CCCCC1)(C(=O)O[C@H]1C[N+]2(CCc3ccccc3F)CCC1CC2)c1ccccc1 |r,wU:1.0,wD:1.8,11.11,(38.09,-9.95,;38.1,-8.41,;38.1,-6.86,;39.44,-6.1,;39.43,-4.56,;38.1,-3.78,;36.76,-4.56,;36.75,-6.11,;39.44,-9.18,;39.45,-10.73,;40.78,-8.4,;42.12,-9.18,;42.12,-10.72,;43.46,-11.48,;43.5,-13.02,;44.86,-13.75,;46.17,-12.94,;46.11,-11.41,;47.41,-10.6,;48.78,-11.33,;48.82,-12.87,;47.51,-13.68,;47.55,-15.21,;44.79,-10.72,;44.79,-9.18,;43.46,-8.39,;42.67,-9.72,;44.16,-10.12,;36.76,-9.17,;35.44,-8.38,;34.1,-9.14,;34.09,-10.68,;35.42,-11.46,;36.75,-10.7,)|
Structure:
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