Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 6
Ligand
BDBM50240510
Substrate
n/a
Meas. Tech.
ChEMBL_838299 (CHEMBL2076247)
IC50
850±n/a nM
Citation
 Mulato, AS; Ho, ES; Cihlar, T Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther 295:10-5 (2000) [PubMed] 
Target
Name:
Solute carrier family 22 member 6
Synonyms:
OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | S22A6_HUMAN | SLC22A6 | hOAT1 | hPAHT | hROAT1
Type:
PROTEIN
Mol. Mass.:
61831.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1487359
Residue:
563
Sequence:
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL
  
Inhibitor
Name:
BDBM50240510
Synonyms:
CHEMBL898 | DIFLUNISAL
Type:
Small organic molecule
Emp. Form.:
C13H8F2O3
Mol. Mass.:
250.1976
SMILES:
OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F
Structure:
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