Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50300271
Substrate
n/a
Meas. Tech.
ChEMBL_840841 (CHEMBL2090624)
Ki
404±n/a nM
Citation
 Tosh, DK; Paoletta, S; Phan, K; Gao, ZG; Jacobson, KA Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions. ACS Med Chem Lett 3:596-601 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50300271
Synonyms:
CHEMBL567224 | N-(2-aminoethyl)-5-(6-(3-chlorobenzylamino)-9-((1S,2R,3S,4R,5R)-3,4-dihydroxybicyclo[3.1.0]hexan-2-yl)-9H-purin-2-yl)pent-4-ynamide
Type:
Small organic molecule
Emp. Form.:
C25H28ClN7O3
Mol. Mass.:
509.988
SMILES:
NCCNC(=O)CCC#Cc1nc(NCc2cccc(Cl)c2)c2ncn([C@@H]3[C@H]4C[C@H]4[C@@H](O)[C@H]3O)c2n1 |r|
Structure:
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