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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50421135
Substrate
n/a
Meas. Tech.
ChEMBL_839529 (CHEMBL2090336)
IC50
9.9±n/a nM
Citation
 Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett 22:5979-83 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha
Type:
Enzyme
Mol. Mass.:
41281.22
Organism:
Mus musculus (mouse)
Description:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography.
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50421135
Synonyms:
CHEMBL2088577
Type:
Small organic molecule
Emp. Form.:
C26H21F2N3O3
Mol. Mass.:
461.46
SMILES:
CCc1ccc(cc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O)C(=O)NC1CC1 |(31.2,-29.1,;32.53,-29.87,;33.87,-29.1,;33.87,-27.56,;35.2,-26.79,;36.53,-27.55,;36.54,-29.1,;35.2,-29.87,;35.2,-31.41,;36.53,-32.17,;37.85,-31.41,;39.18,-32.16,;39.19,-33.7,;40.52,-34.46,;40.53,-36,;39.19,-36.78,;39.2,-38.31,;40.54,-39.08,;40.55,-40.62,;41.87,-38.3,;41.86,-36.76,;43.19,-35.98,;37.86,-34.47,;36.54,-33.71,;35.2,-34.49,;33.87,-33.71,;33.87,-32.18,;32.54,-31.4,;37.86,-26.77,;37.86,-25.23,;39.2,-27.54,;40.53,-26.76,;42.07,-26.76,;41.29,-25.43,)|
Structure:
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