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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50421136
Substrate
n/a
Meas. Tech.
ChEMBL_839529 (CHEMBL2090336)
IC50
8.8±n/a nM
Citation
 Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett 22:5979-83 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha
Type:
Enzyme
Mol. Mass.:
41281.22
Organism:
Mus musculus (mouse)
Description:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography.
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50421136
Synonyms:
CHEMBL2088587
Type:
Small organic molecule
Emp. Form.:
C21H14F2N2O3
Mol. Mass.:
380.3443
SMILES:
COc1ccccc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O |(-12.43,-43.9,;-11.09,-44.67,;-9.75,-43.9,;-9.75,-42.36,;-8.42,-41.59,;-7.08,-42.35,;-7.08,-43.9,;-8.42,-44.68,;-8.41,-46.21,;-7.08,-46.98,;-5.76,-46.21,;-4.44,-46.97,;-4.43,-48.51,;-3.09,-49.27,;-3.08,-50.81,;-4.42,-51.59,;-4.41,-53.13,;-3.08,-53.89,;-3.07,-55.44,;-1.74,-53.11,;-1.75,-51.57,;-.42,-50.79,;-5.75,-49.28,;-7.08,-48.51,;-8.42,-49.3,;-9.75,-48.52,;-9.75,-46.98,;-11.09,-46.21,)|
Structure:
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