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Target
Mitogen-activated protein kinase 11
Ligand
BDBM50421125
Substrate
n/a
Meas. Tech.
ChEMBL_839530 (CHEMBL2090337)
IC50
86±n/a nM
Citation
 Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett 22:5979-83 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP Kinase p38 beta | MK11_MOUSE | Mapk11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | Prkm11 | p38B
Type:
Enzyme
Mol. Mass.:
41390.66
Organism:
Mus musculus (mouse)
Description:
Q9WUI1
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTHEIEQ
  
Inhibitor
Name:
BDBM50421125
Synonyms:
CHEMBL2088586
Type:
Small organic molecule
Emp. Form.:
C20H10F4N2O2
Mol. Mass.:
386.2992
SMILES:
Fc1ccc(Oc2ccc3c(-c4c(F)cccc4F)c(=O)ccn3n2)c(F)c1 |(-3.31,-9.21,;-3.32,-7.66,;-4.65,-6.9,;-4.66,-5.36,;-3.32,-4.59,;-3.33,-3.04,;-4.67,-2.28,;-4.68,-.74,;-6,.02,;-7.32,-.75,;-8.65,.01,;-8.66,1.55,;-9.99,2.32,;-11.34,1.55,;-9.99,3.87,;-8.66,4.64,;-7.32,3.88,;-7.32,2.32,;-5.98,1.56,;-9.99,-.75,;-11.33,.02,;-9.99,-2.29,;-8.66,-3.07,;-7.32,-2.28,;-5.99,-3.05,;-1.99,-5.34,;-.66,-4.56,;-1.98,-6.88,)|
Structure:
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