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Target
Mitogen-activated protein kinase 11
Ligand
BDBM50421136
Substrate
n/a
Meas. Tech.
ChEMBL_839530 (CHEMBL2090337)
IC50
140±n/a nM
Citation
 Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett 22:5979-83 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP Kinase p38 beta | MK11_MOUSE | Mapk11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | Prkm11 | p38B
Type:
Enzyme
Mol. Mass.:
41390.66
Organism:
Mus musculus (mouse)
Description:
Q9WUI1
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTHEIEQ
  
Inhibitor
Name:
BDBM50421136
Synonyms:
CHEMBL2088587
Type:
Small organic molecule
Emp. Form.:
C21H14F2N2O3
Mol. Mass.:
380.3443
SMILES:
COc1ccccc1-c1c2ccc(Oc3ccc(F)cc3F)nn2ccc1=O |(-12.43,-43.9,;-11.09,-44.67,;-9.75,-43.9,;-9.75,-42.36,;-8.42,-41.59,;-7.08,-42.35,;-7.08,-43.9,;-8.42,-44.68,;-8.41,-46.21,;-7.08,-46.98,;-5.76,-46.21,;-4.44,-46.97,;-4.43,-48.51,;-3.09,-49.27,;-3.08,-50.81,;-4.42,-51.59,;-4.41,-53.13,;-3.08,-53.89,;-3.07,-55.44,;-1.74,-53.11,;-1.75,-51.57,;-.42,-50.79,;-5.75,-49.28,;-7.08,-48.51,;-8.42,-49.3,;-9.75,-48.52,;-9.75,-46.98,;-11.09,-46.21,)|
Structure:
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