Reaction Details Report a problem with these data
Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Ligand
BDBM50421231
Substrate
n/a
Meas. Tech.
ChEMBL_840087 (CHEMBL2090691)
Ki
1700000±n/a nM
Citation
 Linsky, TW; Fast, W Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase. Bioorg Med Chem 20:5550-8 (2012) [PubMed]  Article 
Target
Name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms:
DDAH | DDAH1 | DDAH1_HUMAN | Dimethylarginine dimethylaminohydrolase (DDAH-1) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) E78A | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L271G | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L30A | Dimethylarginine dimethylaminohydrolase 1 (DDAH1) | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Type:
Protein
Mol. Mass.:
31116.90
Organism:
Homo sapiens (Human)
Description:
O94760
Residue:
285
Sequence:
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
  
Inhibitor
Name:
BDBM50421231
Synonyms:
CHEMBL2087646
Type:
Small organic molecule
Emp. Form.:
C9H10N2OS
Mol. Mass.:
194.254
SMILES:
NCCSc1nc2ccccc2o1
Structure:
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