Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50040284
Substrate
n/a
Meas. Tech.
ChEMBL_201132 (CHEMBL805753)
IC50
10±n/a nM
Citation
 Myers, AM; Charifson, PS; Owens, CE; Kula, NS; McPhail, AT; Baldessarini, RJ; Booth, RG; Wyrick, SD Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor. J Med Chem 37:4109-17 (1995) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50040284
Synonyms:
3-Chloro-6-methylamino-8-phenyl-5,6,7,8-tetrahydro-naphthalen-2-ol | CHEMBL87321 | trans-3-Chloro-6-methylamino-8-phenyl-5,6,7,8-tetrahydro-naphthalen-2-ol
Type:
Small organic molecule
Emp. Form.:
C17H18ClNO
Mol. Mass.:
287.784
SMILES:
CNC1CC(c2ccccc2)c2cc(O)c(Cl)cc2C1
Structure:
Search PDB for entries with ligand similarity: