Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50423786
Substrate
n/a
Meas. Tech.
ChEMBL_698608 (CHEMBL1647881)
Ki
1.7±n/a nM
Citation
 Munei, Y; Shimamoto, K; Harada, M; Yoshida, T; Chuman, H Correlation analyses on binding affinity of substituted benzenesulfonamides with carbonic anhydrase using ab initio MO calculations on their complex structures (II). Bioorg Med Chem Lett 21:141-4 (2010) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA2 | CAH2_BOVIN | Carbonic anhydrase | Carbonic anhydrase 2 | Carbonic anhydrase II | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29115.93
Organism:
Bos taurus
Description:
n/a
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK
  
Inhibitor
Name:
BDBM50423786
Synonyms:
CHEMBL181397
Type:
Small organic molecule
Emp. Form.:
C7H5F3N2O4S
Mol. Mass.:
270.186
SMILES:
NS(=O)(=O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
Structure:
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