Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50052294
Substrate
n/a
Meas. Tech.
ChEMBL_934969 (CHEMBL2320338)
Ki
40±n/a nM
Citation
 Catarzi, D; Colotta, V; Varano, F; Poli, D; Squarcialupi, L; Filacchioni, G; Varani, K; Vincenzi, F; Borea, PA; Dal Ben, D; Lambertucci, C; Cristalli, G Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies. Bioorg Med Chem 21:283-94 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50052294
Synonyms:
2-Thiophen-2-yl-6H-pyrazolo[1,5-c]quinazolin-5-one | CHEMBL101818
Type:
Small organic molecule
Emp. Form.:
C14H9N3OS
Mol. Mass.:
267.306
SMILES:
O=c1[nH]c2ccccc2c2cc(nn12)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: