Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50423914
Substrate
n/a
Meas. Tech.
ChEMBL_934967 (CHEMBL2320336)
Ki
35±n/a nM
Citation
 Catarzi, D; Colotta, V; Varano, F; Poli, D; Squarcialupi, L; Filacchioni, G; Varani, K; Vincenzi, F; Borea, PA; Dal Ben, D; Lambertucci, C; Cristalli, G Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies. Bioorg Med Chem 21:283-94 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50423914
Synonyms:
CHEMBL2312725
Type:
Small organic molecule
Emp. Form.:
C14H10N4O
Mol. Mass.:
250.2554
SMILES:
Nc1nc2ccccc2c2cc(nn12)-c1ccco1
Structure:
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