Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50381677
Substrate
n/a
Meas. Tech.
ChEMBL_937281 (CHEMBL2318810)
Ki
1.4±n/a nM
Citation
 Nemoto, T; Yamamoto, N; Wada, N; Harada, Y; Tomatsu, M; Ishihara, M; Hirayama, S; Iwai, T; Fujii, H; Nagase, H The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives. Bioorg Med Chem Lett 23:268-72 (2012) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50381677
Synonyms:
CHEMBL1256748 | U-69593
Type:
Small organic molecule
Emp. Form.:
C22H32N2O2
Mol. Mass.:
356.5017
SMILES:
CN([C@H]1C[C@@]2(CCCO2)CC[C@@H]1N1CCCC1)C(=O)Cc1ccccc1 |r|
Structure:
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