Reaction Details Report a problem with these data
Target
DNA repair protein RAD51 homolog 1
Ligand
BDBM39120
Substrate
n/a
Meas. Tech.
ChEMBL_937387 (CHEMBL2319671)
IC50
6820±n/a nM
Citation
 Budke, B; Kalin, JH; Pawlowski, M; Zelivianskaia, AS; Wu, M; Kozikowski, AP; Connell, PP An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity. J Med Chem 56:254-63 (2013) [PubMed]  Article 
Target
Name:
DNA repair protein RAD51 homolog 1
Synonyms:
RAD51 | RAD51A | RAD51_HUMAN | RECA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36960.74
Organism:
Homo sapiens (Human)
Description:
gi_49168602
Residue:
339
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
  
Inhibitor
Name:
BDBM39120
Synonyms:
3-chloranyl-1-(3,4-dichlorophenyl)-4-morpholin-4-yl-pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-3-pyrroline-2,5-quinone | MLS-0067124.0001 | cid_1074953
Type:
Small organic molecule
Emp. Form.:
C14H11Cl3N2O3
Mol. Mass.:
361.608
SMILES:
ClC1=C(N2CCOCC2)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1 |c:1|
Structure:
Search PDB for entries with ligand similarity: