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Target
Acyl-CoA desaturase 1
Ligand
BDBM50425291
Substrate
n/a
Meas. Tech.
ChEMBL_933806 (CHEMBL2321360)
IC50
1800±n/a nM
Citation
 Deng, Y; Yang, Z; Shipps, GW; Lo, SM; West, R; Hwa, J; Zheng, S; Farley, C; Lachowicz, J; van Heek, M; Bass, AS; Sinha, DP; Mahon, CR; Cartwright, ME Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1). Bioorg Med Chem Lett 23:791-6 (2013) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50425291
Synonyms:
CHEMBL2315501
Type:
Small organic molecule
Emp. Form.:
C25H31N3O4
Mol. Mass.:
437.5313
SMILES:
COc1cccc(CN2CCC3(CCN(CC3)C(=O)CNC(C)=O)Oc3ccccc23)c1
Structure:
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