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Target
Laforin
Ligand
BDBM50425807
Substrate
n/a
Meas. Tech.
ChEMBL_937595 (CHEMBL2321064)
IC50
40000±n/a nM
Citation
 He, Y; Xu, J; Yu, ZH; Gunawan, AM; Wu, L; Wang, L; Zhang, ZY Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold. J Med Chem 56:832-42 (2013) [PubMed]  Article 
Target
Name:
Laforin
Synonyms:
EPM2A | EPM2A_HUMAN | LAFPTPase | Lafora PTPase | Laforin
Type:
Protein
Mol. Mass.:
37158.16
Organism:
Homo sapiens (Human)
Description:
O95278
Residue:
331
Sequence:
MRFRFGVVVPPAVAGARPELLVVGSRPELGRWEPRGAVRLRPAGTAAGDGALALQEPGLWLGEVELAAEEAAQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSVCSL
  
Inhibitor
Name:
BDBM50425807
Synonyms:
CHEMBL2316902
Type:
Small organic molecule
Emp. Form.:
C24H13F3O4
Mol. Mass.:
422.3528
SMILES:
OC(=O)c1cc2c(C#Cc3cccc(c3)C(F)(F)F)c(oc2cc1O)-c1ccccc1
Structure:
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