Reaction Details Report a problem with these data
Target
Thioredoxin
Ligand
BDBM50426065
Substrate
n/a
Meas. Tech.
ChEMBL_934906 (CHEMBL2319792)
IC50
240±n/a nM
Citation
 DiRaimondo, TR; Plugis, NM; Jin, X; Khosla, C Selective inhibition of extracellular thioredoxin by asymmetric disulfides. J Med Chem 56:1301-10 (2013) [PubMed]  Article 
Target
Name:
Thioredoxin
Synonyms:
ADF | ATL-derived factor | SASP | Surface-associated sulphydryl protein | THIO_HUMAN | TRDX | TRX | TRX1 | TXN
Type:
PROTEIN
Mol. Mass.:
11732.84
Organism:
Homo sapiens (Human)
Description:
ChEMBL_934906
Residue:
105
Sequence:
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
  
Inhibitor
Name:
BDBM50426065
Synonyms:
CHEMBL2315294
Type:
Small organic molecule
Emp. Form.:
C20H20N2OS2
Mol. Mass.:
368.516
SMILES:
O=C(c1ccccc1)c1ccc2nc(SSC3CCCCC3)[nH]c2c1
Structure:
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