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Target
NEDD8-activating enzyme E1 regulatory subunit
Ligand
BDBM50427034
Substrate
n/a
Meas. Tech.
ChEMBL_939694 (CHEMBL2328919)
IC50
4.7±n/a nM
Citation
 da Silva, SR; Paiva, SL; Lukkarila, JL; Gunning, PT Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes. J Med Chem 56:2165-77 (2013) [PubMed]  Article 
Target
Name:
NEDD8-activating enzyme E1 regulatory subunit
Synonyms:
APP-BP1 | APPBP1 | Amyloid beta precursor protein-binding protein 1, 59 kDa | Amyloid protein-binding protein 1 | NAE1 | Proto-oncogene protein 1 | ULA1_HUMAN
Type:
PROTEIN
Mol. Mass.:
60233.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939705
Residue:
534
Sequence:
MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
  
Inhibitor
Name:
BDBM50427034
Synonyms:
CHEMBL2322194
Type:
Small organic molecule
Emp. Form.:
C21H27N5O4S
Mol. Mass.:
445.535
SMILES:
NS(=O)(=O)OC[C@@H]1C[C@H](C[C@@H]1O)N1CCc2c1ncnc2N[C@H]1CCc2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: