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Target
Sodium- and chloride-dependent GABA transporter 1
Ligand
BDBM50427393
Substrate
n/a
Meas. Tech.
ChEMBL_941202 (CHEMBL2329713)
IC50
>500000±n/a nM
Citation
 Vogensen, SB; Jørgensen, L; Madsen, KK; Borkar, N; Wellendorph, P; Skovgaard-Petersen, J; Schousboe, A; White, HS; Krogsgaard-Larsen, P; Clausen, RP Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization. J Med Chem 56:2160-4 (2013) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 1
Synonyms:
GABA transporter | GABA transporter 1 | Gabt1 | Gat-1 | Gat1 | SC6A1_MOUSE | Slc6a1
Type:
PROTEIN
Mol. Mass.:
67006.26
Organism:
Mus musculus
Description:
ChEMBL_788602
Residue:
599
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
  
Inhibitor
Name:
BDBM50427393
Synonyms:
CHEMBL2326028
Type:
Small organic molecule
Emp. Form.:
C9H13NO2
Mol. Mass.:
167.205
SMILES:
CNC1C2CC(C=C2)C1C(O)=O |c:6,THB:1:2:6.7:4,9:8:6.7:4|
Structure:
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