Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50427402
Substrate
n/a
Meas. Tech.
ChEMBL_941210 (CHEMBL2329721)
Ki
47±n/a nM
Citation
 Yang, P; Wang, L; Feng, R; Almehizia, AA; Tong, Q; Myint, KZ; Ouyang, Q; Alqarni, MH; Wang, L; Xie, XQ Novel triaryl sulfonamide derivatives as selective cannabinoid receptor 2 inverse agonists and osteoclast inhibitors: discovery, optimization, and biological evaluation. J Med Chem 56:2045-58 (2013) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50427402
Synonyms:
CHEMBL2326310
Type:
Small organic molecule
Emp. Form.:
C28H38N2O2S
Mol. Mass.:
466.679
SMILES:
CCN(CC)c1ccc(CN([C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)S(=O)(=O)c2ccc(C)cc2)cc1 |r,TLB:18:13:20:16.17.19,18:17:14.13.12:20|
Structure:
Search PDB for entries with ligand similarity: