Reaction Details Report a problem with these data
Target
WD repeat-containing protein 5
Ligand
BDBM50428236
Substrate
n/a
Meas. Tech.
ChEMBL_946433 (CHEMBL2339613)
Kd
1400±n/a nM
Citation
 Bolshan, Y; Getlik, M; Kuznetsova, E; Wasney, GA; Hajian, T; Poda, G; Nguyen, KT; Wu, H; Dombrovski, L; Dong, A; Senisterra, G; Schapira, M; Arrowsmith, CH; Brown, PJ; Al-Awar, R; Vedadi, M; Smil, D Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett 4:353-7 (2013) [PubMed]  Article 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM50428236
Synonyms:
CHEMBL1457864
Type:
Small organic molecule
Emp. Form.:
C19H22N4O4
Mol. Mass.:
370.4024
SMILES:
COc1cccc(c1)C(=O)Nc1cc(ccc1N1CCN(C)CC1)[N+]([O-])=O
Structure:
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