Reaction Details Report a problem with these data
Target
Hepatocyte growth factor
Ligand
BDBM50428279
Substrate
n/a
Meas. Tech.
ChEMBL_946456 (CHEMBL2340053)
Kd
1950±n/a nM
Citation
 Liang, Z; Ai, J; Ding, X; Peng, X; Zhang, D; Zhang, R; Wang, Y; Liu, F; Zheng, M; Jiang, H; Liu, H; Geng, M; Luo, C Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway. ACS Med Chem Lett 4:408-13 (2013) [PubMed]  Article 
Target
Name:
Hepatocyte growth factor
Synonyms:
HGF | HGF_HUMAN | HPTA
Type:
PROTEIN
Mol. Mass.:
83154.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_946456
Residue:
728
Sequence:
MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS
  
Inhibitor
Name:
BDBM50428279
Synonyms:
CHEMBL2337901
Type:
Small organic molecule
Emp. Form.:
C40H24N4O10S2
Mol. Mass.:
784.77
SMILES:
Nc1c2C(=O)c3ccccc3C(=O)c2c(Nc2ccc(cc2)-c2ccc(Nc3cc(c(N)c4C(=O)c5ccccc5C(=O)c34)S([O-])(=O)=O)cc2)cc1S([O-])(=O)=O
Structure:
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