Reaction Details Report a problem with these data
Target
HTH-type transcriptional regulator MgrA
Ligand
BDBM11979
Substrate
n/a
Meas. Tech.
ChEMBL_944630 (CHEMBL2339937)
IC50
8000±n/a nM
Citation
 Gordon, CP; Williams, P; Chan, WC Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective. J Med Chem 56:1389-404 (2013) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator MgrA
Synonyms:
HTH-type transcriptional regulator mgrA (MgrA) | MGRA_STAAU | Regulator of autolytic activity | mgr | mgrA
Type:
Protein
Mol. Mass.:
17090.77
Organism:
Staphylococcus aureus
Description:
P0C1S0
Residue:
147
Sequence:
MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVDLIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK
  
Inhibitor
Name:
BDBM11979
Synonyms:
5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxybenzoic acid | CHEMBL115145 | MgrA inhibitor, 1 | chemical diversity library compound 4
Type:
Small organic molecule
Emp. Form.:
C15H12O6
Mol. Mass.:
288.2522
SMILES:
OC(=O)c1cc(Cc2ccc(O)c(c2)C(O)=O)ccc1O
Structure:
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