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Target
Palmitoyl-protein thioesterase 1
Ligand
BDBM50429511
Substrate
n/a
Meas. Tech.
ChEMBL_943688 (CHEMBL2344832)
IC50
2000±n/a nM
Citation
 Boyd, RE; Lee, G; Rybczynski, P; Benjamin, ER; Khanna, R; Wustman, BA; Valenzano, KJ Pharmacological chaperones as therapeutics for lysosomal storage diseases. J Med Chem 56:2705-25 (2013) [PubMed]  Article 
Target
Name:
Palmitoyl-protein thioesterase 1
Synonyms:
CLN1 | PPT | PPT-1 | PPT1 | PPT1_HUMAN | Palmitoyl-protein hydrolase 1
Type:
PROTEIN
Mol. Mass.:
34193.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_943688
Residue:
306
Sequence:
MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG
  
Inhibitor
Name:
BDBM50429511
Synonyms:
CHEMBL2332876
Type:
Small organic molecule
Emp. Form.:
C59H103N15O13
Mol. Mass.:
1230.5418
SMILES:
CCCCCCCCCCCCCCCC(=O)NC[C@H](NC(=O)CNC(=O)CCNc1ccc([N+]([O-])=O)c2nonc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O |r|
Structure:
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