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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50430250
Substrate
n/a
Meas. Tech.
ChEMBL_943353 (CHEMBL2340861)
EC50
32±n/a nM
Citation
 McDonald, IM; Mate, RA; Zusi, FC; Huang, H; Post-Munson, DJ; Ferrante, MA; Gallagher, L; Bertekap, RL; Knox, RJ; Robertson, BJ; Harden, DG; Morgan, DG; Lodge, NJ; Dworetzky, SI; Olson, RE; Macor, JE Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 23:1684-8 (2013) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50430250
Synonyms:
CHEMBL2332468
Type:
Small organic molecule
Emp. Form.:
C26H29N3O2
Mol. Mass.:
415.5274
SMILES:
CC(=O)NCc1cccc(c1)-c1cc(=O)n(CC2CN3CCC2CC3)c2ccccc12 |(23.34,-47.59,;22,-46.82,;22,-45.28,;20.68,-47.59,;19.34,-46.82,;18.01,-47.59,;16.68,-46.82,;15.34,-47.59,;15.34,-49.13,;16.67,-49.89,;18.01,-49.13,;16.67,-51.42,;18.02,-52.21,;18.02,-53.76,;19.35,-54.54,;16.67,-54.53,;16.67,-56.07,;15.33,-56.84,;14,-56.06,;12.67,-56.82,;12.66,-58.36,;13.99,-59.14,;15.33,-58.37,;14.19,-56.81,;13.43,-58.14,;15.33,-53.76,;14,-54.53,;12.67,-53.75,;12.67,-52.21,;14,-51.44,;15.33,-52.2,)|
Structure:
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