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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50430251
Substrate
n/a
Meas. Tech.
ChEMBL_943353 (CHEMBL2340861)
EC50
14±n/a nM
Citation
 McDonald, IM; Mate, RA; Zusi, FC; Huang, H; Post-Munson, DJ; Ferrante, MA; Gallagher, L; Bertekap, RL; Knox, RJ; Robertson, BJ; Harden, DG; Morgan, DG; Lodge, NJ; Dworetzky, SI; Olson, RE; Macor, JE Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 23:1684-8 (2013) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50430251
Synonyms:
CHEMBL2332469
Type:
Small organic molecule
Emp. Form.:
C25H29N3O3S
Mol. Mass.:
451.581
SMILES:
CS(=O)(=O)NCc1cccc(c1)-c1cc(=O)n(CC2CN3CCC2CC3)c2ccccc12 |(12.11,-47.63,;10.77,-46.86,;9.99,-45.52,;11.54,-45.52,;9.44,-47.63,;8.11,-46.86,;6.77,-47.63,;5.44,-46.86,;4.1,-47.64,;4.11,-49.17,;5.44,-49.94,;6.77,-49.17,;5.44,-51.47,;6.79,-52.25,;6.78,-53.81,;8.11,-54.58,;5.44,-54.58,;5.43,-56.12,;4.1,-56.88,;2.77,-56.1,;1.44,-56.86,;1.43,-58.4,;2.76,-59.18,;4.1,-58.42,;2.95,-56.85,;2.19,-58.19,;4.1,-53.8,;2.77,-54.57,;1.43,-53.8,;1.44,-52.25,;2.76,-51.48,;4.1,-52.25,)|
Structure:
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