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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50430306
Substrate
n/a
Meas. Tech.
ChEMBL_943799 (CHEMBL2346248)
EC50
4100±n/a nM
Citation
 Poslusney, MS; Melancon, BJ; Gentry, PR; Sheffler, DJ; Bridges, TM; Utley, TJ; Daniels, JS; Niswender, CM; Conn, PJ; Lindsley, CW; Wood, MR Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule. Bioorg Med Chem Lett 23:1860-4 (2013) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50430306
Synonyms:
CHEMBL2333480
Type:
Small organic molecule
Emp. Form.:
C27H28F2N4O
Mol. Mass.:
462.5342
SMILES:
Cn1cc(cn1)-c1cc(F)c(CN2C(=O)C3(CCN(C3)C3CCCC3)c3ccccc23)cc1F
Structure:
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