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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50431037
Substrate
n/a
Meas. Tech.
ChEMBL_947846 (CHEMBL2343122)
Ki
15±n/a nM
Citation
 Díaz, JL; Christmann, U; Fernández, A; Luengo, M; Bordas, M; Enrech, R; Carro, M; Pascual, R; Burgueño, J; Merlos, M; Benet-Buchholz, J; Cerón-Bertran, J; Ramírez, J; Reinoso, RF; Fernández de Henestrosa, AR; Vela, JM; Almansa, C Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selectives1 receptor ligands. J Med Chem 56:3656-65 (2013) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50431037
Synonyms:
CHEMBL2338759
Type:
Small organic molecule
Emp. Form.:
C29H40N2O2
Mol. Mass.:
448.6401
SMILES:
CC(C)CCOc1ccc2N[C@H](C3CCN(Cc4ccccc4)CC3)[C@@H]3CCCO[C@@H]3c2c1 |r|
Structure:
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