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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50432073
Substrate
n/a
Meas. Tech.
ChEMBL_950413 (CHEMBL2350909)
Ki
>1000±n/a nM
Citation
 Meyer, C; Neue, B; Schepmann, D; Yanagisawa, S; Yamaguchi, J; Würthwein, EU; Itami, K; Wünsch, B Improvement ofs1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones. Bioorg Med Chem 21:1844-56 (2013) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50432073
Synonyms:
CHEMBL2349451
Type:
Small organic molecule
Emp. Form.:
C41H33NO2S
Mol. Mass.:
603.771
SMILES:
O=C1OC2(CCN(Cc3ccccc3)CC2)c2c(sc(c12)-c1ccc(cc1)-c1ccccc1)-c1ccc(cc1)-c1ccccc1
Structure:
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